{"id":33282,"date":"2026-04-24T07:05:33","date_gmt":"2026-04-24T07:05:33","guid":{"rendered":"https:\/\/lifelonghearing.com\/sk\/?p=33282"},"modified":"2026-04-24T07:05:33","modified_gmt":"2026-04-24T07:05:33","slug":"da-sa-porucha-sluchu-vyliecit","status":"publish","type":"post","link":"https:\/\/lifelonghearing.com\/sk\/da-sa-porucha-sluchu-vyliecit\/","title":{"rendered":"D\u00e1 sa porucha sluchu vylie\u010di\u0165?"},"content":{"rendered":"

Prof. Christoph Arnoldner o g\u00e9novej terapii sluchu a lieku AC102<\/h1><\/div>

Prof. Christoph Arnoldner hovor\u00ed o svojich priorit\u00e1ch ako nov\u00fd prim\u00e1r ORL Kliniky Univerzitnej nemocnice vo Viedni a o aktu\u00e1lnych v\u00fdskumn\u00fdch projektoch, ktor\u00e9 by mohli od z\u00e1kladov zmeni\u0165 lie\u010dbu por\u00fach sluchu.<\/strong><\/p>\n

Hlavn\u00fd zdroj: podcast \u201eH\u00f6rgang\u201c s Martinom Krenekom\u2011Burgerom<\/em><\/p>\n<\/div>

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Prof. Dr. Christoph Arnoldner, odborn\u00edk na u\u0161n\u00e9 lek\u00e1rstvo a chirurgiu lebe\u010dnej b\u00e1zy s medzin\u00e1rodn\u00fdmi sk\u00fasenos\u0165ami, je mnoh\u00fdm pou\u017e\u00edvate\u013eom KI zn\u00e1my ako \u0161pecialista a chirurg KI. Od roku 2022 vedie viedensk\u00e9 Christian Doppler laborat\u00f3rium pre v\u00fdskum vn\u00fatorn\u00e9ho ucha, ktor\u00e9 s\u00e1m zalo\u017eil. Spolu so svoj\u00edm t\u00edmom sa venuje v\u00fdskumu \u00fa\u010dinn\u00fdch l\u00e1tok na lie\u010dbu straty sluchu.<\/em><\/p>\n

Terapie, ktor\u00e9 vznikaj\u00fa v tomto laborat\u00f3riu aj v \u010fal\u0161\u00edch v\u00fdskumn\u00fdch centr\u00e1ch, by mohli z\u00e1sadne zmeni\u0165 sp\u00f4sob, ak\u00fdm sa straty sluchu lie\u010dia, a v bud\u00facnosti pon\u00faknu\u0165 nov\u00e9 mo\u017enosti mnoh\u00fdm pacientom. Treba v\u0161ak poveda\u0165, \u017ee mimo klinick\u00fdch \u0161t\u00fadi\u00ed zatia\u013e nie je \u017eiadna z t\u00fdchto terapi\u00ed dostupn\u00e1 pre \u013eud\u00ed, ktor\u00ed potrebuj\u00fa pomoc v s\u00fa\u010dasnosti. A osved\u010den\u00e9 kochle\u00e1rne implant\u00e1ty, skr\u00e1tene KI, zostan\u00fa k\u013e\u00fa\u010dovou vo\u013ebou i v bud\u00facnosti. Prof. Arnoldner v rozhovore vysvet\u013euje, \u010do by sa mohlo v bud\u00facnosti skuto\u010dne zmeni\u0165. Od za\u010diatku m\u00e1ja p\u00f4sob\u00ed ako prim\u00e1r ORL Kliniky Univerzitnej nemocnice vo Viedni.<\/em><\/p>\n

MK\u2011B: Od m\u00e1ja ste prednostom ORL Univerzitnej kliniky vo Viedni \u2013 ak\u00e9 s\u00fa va\u0161e priority?<\/strong><\/em><\/div>\n
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Ve\u013emi ma te\u0161\u00ed, \u017ee preber\u00e1m kliniku, na ktorej m\u00f4\u017eeme pacientom poskytova\u0165 \u0161irok\u00e9 spektrum starostlivosti na najmodernej\u0161ej \u00farovni. Rob\u00edme ve\u013ek\u00e9 onkologick\u00e9<\/p>\n

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Prof. Dr. Christoph Arnoldner, founder and director of the Christian Doppler Laboratory for Inner Ear Research in Vienna, has been the head of the ENT University Clinic Vienna since May 1, 2025. \u00a9MedUni Vienna\/feelimage<\/p><\/div>\n

oper\u00e1cie, ale aj estetick\u00e9 z\u00e1kroky \u010di kochle\u00e1rne implant\u00e1cie pri poruch\u00e1ch sluchu. Operujeme deti rovnako ako star\u0161\u00edch pacientov.<\/p>\n

\u010eal\u0161ou d\u00f4le\u017eitou oblas\u0165ou kliniky je vzdel\u00e1vanie lek\u00e1rov. Patr\u00ed sem tie\u017e postgradu\u00e1lne vzdel\u00e1vanie v medzin\u00e1rodne akreditovan\u00fdch jednoro\u010dn\u00fdch a\u017e dvojro\u010dn\u00fdch klinick\u00fdch \u0161pecializa\u010dn\u00fdch programoch na \u0161pi\u010dkov\u00fdch pracovisk\u00e1ch v Kanade, USA, Austr\u00e1lii a Anglicku. Zhroma\u017eden\u00e9 poznatky maj\u00fa n\u00e1sledne prispie\u0165 k optim\u00e1lnej starostlivosti o pacientov.<\/p>\n

Ve\u013emi mi z\u00e1le\u017e\u00ed na podpore v\u00fdskumu, a\u00a0to najm\u00e4 v oblastiach, ktor\u00e9 zatia\u013e nemaj\u00fa tak\u00fd status, ak\u00fd by si zasl\u00fa\u017eili. Sna\u017e\u00edme sa v\u00fdskum zintenz\u00edvni\u0165 spolupr\u00e1cou s in\u00fdmi klinikami. M\u00f4j vlastn\u00fd v\u00fdskum sa s\u00fastre\u010fuje na sluch. Ide o to, ako pomocou nov\u00fdch l\u00e1tok, implant\u00e1tov alebo g\u00e9novej terapie obnovi\u0165 sluch.<\/p>\n

MK\u2011B: \u010co je vlastne viedensk\u00e1 ORL klinika? <\/em><\/strong><\/p>\n

Sme najstar\u0161ia ORL klinika na svete. Viede\u0148 bola p\u00f4sobiskom Adama Politzera, v\u00fdznamn\u00e9ho otolaryngol\u00f3ga 19. a za\u010diatku 20. storo\u010dia, <\/em>a pr\u00e1ve tu sa pou\u017e\u00edval aj prv\u00fd viac-kan\u00e1lov\u00fd kochle\u00e1rny implant\u00e1t, v\u010faka ktor\u00e9mu dok\u00e1\u017eeme skuto\u010dne obnovi\u0165 funkciu sluchov\u00e9ho org\u00e1nu.<\/p>\n

Ale nem\u00f4\u017eeme \u017ei\u0165 len z minulosti: dnes patr\u00edme medzi najlep\u0161ie ORL kliniky na svete \u2013 pokia\u013e ide o starostlivos\u0165 o pacientov, ale \u010doraz viac i v oblasti v\u00fdskumu.<\/p>\n

MK\u2011B: Transla\u010dn\u00fd v\u00fdskum \u2013 teda prepojenie v\u00fdskumu s klinickou praxou \u2013 je jedn\u00fdm z hlavn\u00fdch cie\u013eov v\u00e1\u0161ho laborat\u00f3ria. <\/em><\/strong><\/p>\n

To je na\u0161a siln\u00e1 str\u00e1nka ako lek\u00e1rov \u2013 v\u00fdskumn\u00edkov. Otorinolaryngol\u00f3gia nie je \u00fastredn\u00fdm predmetom a zaober\u00e1 sa aj ve\u013emi jemn\u00fdmi \u0161trukt\u00farami. Mnoh\u00e9 procesy \u2013 poruchy sluchu, tinitus, strata \u010duchu, alergie \u2013 e\u0161te st\u00e1le nedok\u00e1\u017eeme uspokojivo vysvetli\u0165. Ako klinici presne vid\u00edme, kde je probl\u00e9m. Vo v\u00fdskume sa na to zameriavame a rob\u00edme v\u0161etko pre to, aby sa v\u00fdsledky \u010do najr\u00fdchlej\u0161ie dostali na kliniku.<\/p>\n

Na svete je pribli\u017ene 1,5 miliardy \u013eud\u00ed s poruchou sluchu \u2013 teda pribli\u017ene to\u013eko, ako \u013eud\u00ed s vysok\u00fdm krvn\u00fdm tlakom. Na vysok\u00fd tlak existuje viac ako 500 lie\u010debn\u00fdch postupov, ale ani jeden schv\u00e1len\u00fd liek, ktor\u00fd by dok\u00e1zal obnovi\u0165 sluch. Je ve\u013emi frustruj\u00face, ke\u010f mus\u00edme pacientom s n\u00e1hlou stratou sluchu a tinitom poveda\u0165: \u201eVlastne presne nevieme, \u010do sa v\u00e1m teraz deje vo vn\u00fatornom uchu.\u201c<\/p>\n

Chceme lep\u0161ie pochopi\u0165, \u010do sa vo vn\u00fatornom uchu deje pri strate sluchu! A chceme n\u00e1js\u0165 nov\u00e9 lie\u010div\u00e1, ktor\u00e9 na\u0161im pacientom nie\u010do pon\u00faknu!<\/p>\n

_________ _ _________<\/p>\n

MK\u2011B: Spolu so svoj\u00edm t\u00edmom budete sk\u00fama\u0165 \u00fa\u010dinn\u00fa l\u00e1tku AC102, ktor\u00e1 prin\u00e1\u0161a nov\u00fa n\u00e1dej pri ak\u00fatnej n\u00e1hlej strate sluchu. <\/em><\/strong><\/p>\n

V s\u00fa\u010dasnosti pri n\u00e1hlej strate sluchu alebo tinite pod\u00e1vame vysok\u00e9 d\u00e1vky kortiz\u00f3nu \u2013 mus\u00edme si v\u0161ak uvedomi\u0165, \u017ee \u00faspechy s\u00fa \u010dasto skromn\u00e9. Pred takmer desiatimi rokmi n\u00e1s oslovila mal\u00e1 nemeck\u00e1 farmaceutick\u00e1 spolo\u010dnos\u0165, odno\u017e (spin\u2011off) Charit\u00e9. Po\u017eiadali n\u00e1s, aby sme sa pozreli na ich nov\u00fa \u00fa\u010dinn\u00fa l\u00e1tku: tajomne znej\u00facu AC102 Pozn\u00e1mka: v angli\u010dtine sa vyslovuje ako: \u201eA-C-one-O-two\u201c. <\/em>Skratka AC znamen\u00e1 \u201eAudioCure\u201c, \u010do je n\u00e1zov spolo\u010dnosti, ktor\u00e1 t\u00fato l\u00e1tku vyv\u00edja.<\/p>\n

V posledn\u00fdch rokoch sme t\u00fato \u00fa\u010dinn\u00fa l\u00e1tku posunuli z Petriho misky cez zvieracie modely a\u017e do s\u00fa\u010dasnej f\u00e1zy 2 klinickej \u0161t\u00fadie. To znamen\u00e1, \u017ee sa teraz testuje v rozsiahlej multicentrickej \u0161t\u00fadii v mnoh\u00fdch eur\u00f3pskych krajin\u00e1ch u pacientov s ak\u00fatnou n\u00e1hlou stratou sluchu. Ver\u00edme, \u017ee tento liek by mohol v dlhodobom horizonte skuto\u010dne zmeni\u0165 mo\u017enosti lie\u010dby.<\/p>\n

GG: Pre\u010do teda lek\u00e1ri doteraz pod\u00e1vali kortiz\u00f3n? <\/em><\/strong><\/p>\n

\u010co sa presne deje vo vn\u00fatornom uchu pri n\u00e1hlej strate sluchu, zatia\u013e nevieme, a je to jedna z t\u00e9m, ktor\u00fdm chceme v na\u0161om laborat\u00f3riu lep\u0161ie porozumie\u0165. Predpoklad\u00e1 sa v\u0161ak, \u017ee u \u010dasti pacientov sp\u00fa\u0161\u0165a stratu sluchu z\u00e1pal vo vn\u00fatornom uchu \u2013 aspo\u0148 u niektor\u00fdch pacientov \u2013 a pr\u00e1ve tam nastupuje kortiz\u00f3n, ktor\u00fd je prirodzen\u00fdm horm\u00f3nom v\u00a0tele a ve\u013emi \u00fa\u010dinne tlm\u00ed z\u00e1pal, av\u0161ak nem\u00e1 \u017eiadny priazniv\u00fd \u00fa\u010dinok na nervov\u00e9 bunky a vl\u00e1kna.<\/p>\n

MK\u2011B: V \u010dom sa l\u00ed\u0161i nov\u00fd pr\u00edstup?<\/em><\/strong><\/p>\n

AC102 nem\u00e1 len protiz\u00e1palov\u00e9 \u00fa\u010dinky, ale skuto\u010dne chr\u00e1ni aj nervy. Strata sluchu ve\u013emi \u00fazko s\u00favis\u00ed s t\u00fdm, \u017ee pribli\u017ene 13 000 mikrometrov ve\u013ek\u00fdch zmyslov\u00fdch buniek v uchu \u2013 ak sa raz po\u0161kodia \u2013 sa u\u017e neobnovia. Pomocou AC102 dok\u00e1\u017eeme tieto zmyslov\u00e9 bunky chr\u00e1ni\u0165, najm\u00e4 prechod medzi vl\u00e1skovou bunkou a nervov\u00fdm vl\u00e1knom. To m\u00e1 vplyv na samotn\u00fa stratu sluchu a regener\u00e1ciu.<\/p>\n

GG: D\u00e1 sa predpoklada\u0165, \u017ee u existuj\u00facich pou\u017e\u00edvate\u013eov KI alebo u nelie\u010den\u00fdch pacientov, ktor\u00ed s\u00fa dlhodobo nepo\u010duj\u00faci, AC102 sluch neobnov\u00ed? <\/em><\/strong><\/p>\n

Presne tak. Ak sa AC102 pod\u00e1 v\u010das, sluch by sa mal regenerova\u0165, preto\u017ee sa preuk\u00e1zal ve\u013emi pozit\u00edvny \u00fa\u010dinok na neur\u00f3ny. Okrem toho AC102 poskytuje ove\u013ea \u00fa\u010dinnej\u0161iu ochranu zvy\u0161kov\u00e9ho sluchu pri kochle\u00e1rnej implant\u00e1cii ne\u017e v s\u00fa\u010dasnosti pou\u017e\u00edvan\u00fd kortiz\u00f3n, \u010do by mohlo prinies\u0165 z\u00e1sadn\u00fa v\u00fdhodu.<\/p>\n

MK\u2011B: Ako AC102 pom\u00e1ha zachova\u0165 zvy\u0161kov\u00fd sluch? <\/em><\/strong><\/p>\n

KI implantujeme pacientom, u ktor\u00fdch u\u017e na\u010d\u00favacie pr\u00edstroje neposta\u010duj\u00fa. V posledn\u00fdch rokoch sa v\u0161ak uk\u00e1zalo, \u017ee KI pom\u00e1haj\u00fa aj pacientom, ktor\u00ed e\u0161te maj\u00fa ur\u010dit\u00fd zvy\u0161kov\u00fd sluch. A pr\u00e1ve ten chceme zachova\u0165, preto\u017ee kombin\u00e1cia zachovan\u00e9ho zvy\u0161kov\u00e9ho sluchu a kochle\u00e1rneho implant\u00e1tu je lep\u0161ia ne\u017e samotn\u00fd implant\u00e1t.<\/p>\n

Pri kochle\u00e1rnej implant\u00e1cii zav\u00e1dzame do kochley elektr\u00f3dov\u00fd zv\u00e4zok. T\u00fdm otv\u00e1rame \u201eposv\u00e4tn\u00fd\u201c priestor vn\u00fatorn\u00e9ho ucha: \u010do za norm\u00e1lnych okolnost\u00ed vedie k strate sluchu. Preto mus\u00edme pracova\u0165 na technik\u00e1ch, ktor\u00e9 zvy\u0161kov\u00fd sluch chr\u00e1nia. Patr\u00ed sem jemn\u00e1 chirurgick\u00e1 technika: mimoriadne \u0161etrn\u00e9 otvorenie slim\u00e1ka, zav\u00e1dzanie netraumatick\u00fdch elektr\u00f3dov\u00fdch nosi\u010dov, ale aj pod\u00e1vanie l\u00e1tok, ktor\u00e9 chr\u00e1nia \u0161trukt\u00fary vn\u00fatorn\u00e9ho ucha.<\/p>\n

A tu vstupuje do hry AC102: ke\u010f do vn\u00fatorn\u00e9ho ucha vlo\u017e\u00edme cudz\u00ed predmet, nevyhnutne to vyvol\u00e1 z\u00e1pal. AC102 tento z\u00e1palov\u00fd proces spoma\u013euje a chr\u00e1ni spojenia medzi vl\u00e1skov\u00fdmi bunkami vn\u00fatorn\u00e9ho ucha a nervov\u00fdmi vl\u00e1knami. Moment\u00e1lne prebieha f\u00e1za 2 klinickej \u0161t\u00fadie u pacientov s n\u00e1hlou stratou sluchu. Ak bud\u00fa v\u00fdsledky pozit\u00edvne, bude nasledova\u0165 f\u00e1za 3 a liek sa bude hodnoti\u0165 aj pre \u010fal\u0161ie indik\u00e1cie \u2013 napr\u00edklad v r\u00e1mci ochrany zvy\u0161kov\u00e9ho sluchu po\u010das kochle\u00e1rnej implant\u00e1cie.<\/p>\n

_________ _ _________<\/p>\n

MK\u2011B: Od minul\u00e9ho roka prib\u00fada tie\u017e \u010doraz viac \u0161t\u00fadi\u00ed, ktor\u00e9 ukazuj\u00fa, \u017ee g\u00e9nov\u00e1 terapia m\u00f4\u017ee by\u0165 cestou pri lie\u010dbe straty sluchu. <\/em><\/strong><\/p>\n

A\u017e doned\u00e1vna sme u pacientov s n\u00e1hlou stratou sluchu \u2013 pozn\u00e1mka: okrem audiologick\u00fdch testov <\/em>\u2013 pou\u017e\u00edvali len zobrazovacie met\u00f3dy. Genetick\u00e9 pozadie sa sk\u00famalo iba vo vybran\u00fdch pr\u00edpadoch. Dnes je genetick\u00e9 vy\u0161etrenie jedn\u00fdm zo \u0161tandardn\u00fdch testov. A pr\u00e1ve teraz sa sna\u017e\u00edme tento pr\u00edstup pevne etablova\u0165, preto\u017ee genetick\u00e9 pozadie zohr\u00e1va ve\u013ek\u00fa \u00falohu. Strata sluchu toti\u017e nie je v\u017edy rovnak\u00e1.<\/p>\n

Konkr\u00e9tne: prv\u00e9 deti s\u00a0hluchotou sp\u00f4sobenou deficitom otoferl\u00ednu, ve\u013emi \u0161pecifickou vrodenou poruchou sluchu, u\u017e dostali g\u00e9nov\u00fa terapiu \u2013 a dnes po\u010duj\u00fa. Pozn\u00e1me viac ako 200 foriem genetickej hluchoty.[1]<\/a><\/sup> Hluchota sp\u00f4soben\u00e1 deficitom otoferl\u00ednu je jednou z nich a s pribli\u017ene 200 000 postihnut\u00fdmi na svete sa pova\u017euje za \u201ezriedkav\u00fa\u201c. No pr\u00e1ve pre t\u00fato skupinu sa teraz objavila n\u00e1dej. <\/em><\/p>\n

Deti s\u00a0hluchotou sp\u00f4sobenou deficitom otoferl\u00ednu maj\u00fa norm\u00e1lne vn\u00fatorn\u00e9 ucho, norm\u00e1lne vl\u00e1skov\u00e9 bunky, ale t\u00fdmto bunk\u00e1m ch\u00fdba jedin\u00fd prote\u00edn: otoferl\u00edn. Bez neho sa neuvo\u013e\u0148uje pren\u00e1\u0161a\u010d sign\u00e1lu potrebn\u00fd na po\u010dutie. Nov\u00e1 terapia doprav\u00ed ch\u00fdbaj\u00facu genetick\u00fa inform\u00e1ciu do vl\u00e1skov\u00fdch buniek vn\u00fatorn\u00e9ho ucha, pren\u00e1\u0161a\u010d sa op\u00e4\u0165 uvo\u013e\u0148uje a: tieto deti skuto\u010dne po\u010duj\u00fa! A to dokonca bez kochle\u00e1rneho implant\u00e1tu.<\/p>\n

MK\u2011B: Kde vid\u00edte najv\u00e4\u010d\u0161\u00ed potenci\u00e1l v lie\u010dbe por\u00fach sluchu: v implant\u00e1toch, lie\u010debnej terapii alebo genetick\u00fdch \u00faprav\u00e1ch? <\/em><\/strong><\/p>\n

Bud\u00facnos\u0165 bude pravdepodobne kombin\u00e1ciou v\u0161etk\u00fdch pr\u00edstupov. KI budeme na\u010falej potrebova\u0165, aby sme pomohli ve\u013ek\u00e9mu po\u010dtu pacientov. Av\u0161ak existuj\u00fa ur\u010dit\u00e9 genetick\u00e9 typy por\u00fach sluchu, pri ktor\u00fdch bude g\u00e9nov\u00e1 terapia zohr\u00e1va\u0165 hlavn\u00fa \u00falohu. A existuj\u00fa aj kombinovan\u00e9 pr\u00edstupy, pri ktor\u00fdch pomocou g\u00e9novej terapie \u2013 zameranej na nervov\u00e9 bunky vn\u00fatorn\u00e9ho ucha \u2013 dok\u00e1\u017eeme pom\u00f4c\u0165 pacientom s KI po\u010du\u0165 e\u0161te lep\u0161ie so svojimi implant\u00e1tmi.<\/p>\n

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Referencie<\/h4>\n
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  1. <\/a>Prof. Dr. Ellen Reisinger Gene Therapy Heals Children with Congenital Deafness | Tagesschau.de<\/a> \u2191<\/a><\/li>\n<\/ol>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

    Prof. Christoph Arnoldner hovor\u00ed o svojich priorit\u00e1ch ako nov\u00fd prim\u00e1r ORL Kliniky Univerzitnej nemocnice vo Viedni a o aktu\u00e1lnych v\u00fdskumn\u00fdch projektoch, ktor\u00e9 by mohli od z\u00e1kladov zmeni\u0165 lie\u010dbu por\u00fach sluchu.<\/p>\n","protected":false},"author":10,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[411],"tags":[],"class_list":["post-33282","post","type-post","status-publish","format-standard","hentry","category-zdravie"],"yoast_head":"\nD\u00e1 sa porucha sluchu vylie\u010di\u0165? - Slovak<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lifelonghearing.com\/sk\/da-sa-porucha-sluchu-vyliecit\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"D\u00e1 sa porucha sluchu vylie\u010di\u0165? 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