{"id":32511,"date":"2026-04-29T09:16:37","date_gmt":"2026-04-29T09:16:37","guid":{"rendered":"https:\/\/lifelonghearing.com\/lt\/?p=32511"},"modified":"2026-04-29T09:16:37","modified_gmt":"2026-04-29T09:16:37","slug":"ar-klausos-praradima-bus-galima-atkurti","status":"publish","type":"post","link":"https:\/\/lifelonghearing.com\/lt\/ar-klausos-praradima-bus-galima-atkurti\/","title":{"rendered":"Ar klausos praradim\u0105 bus galima atkurti?"},"content":{"rendered":"

Prof. Christoph Arnoldner apie gen\u0173 terapij\u0105 klausos sutrikimams ir vaist\u0105 AC102<\/h1><\/div>

Prof. Christoph Arnoldner pasakoja apie savo prioritetus, tapus naujuoju Vienos universiteto LOR klinikos vadovu, ir apie dabartinius mokslinius projektus, galin\u010dius i\u0161 esm\u0117s pakeisti klausos terapij\u0105.<\/strong><\/p>\n

Pagrindinis \u0161altinis: tinklalaid\u0117 \u201eH\u00f6rgang\u201c su Martin Krenek-Burger<\/em><\/p>\n<\/div>

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Prof. dr. Christoph Arnoldner \u2013 tarptautin\u0117s patirties turintis aus\u0173 medicinos ir kaukol\u0117s pagrindo chirurgijos ekspertas, daugeliui KI naudotoj\u0173 \u017einomas kaip kochlearini\u0173 implant\u0173 specialistas ir chirurgas. Nuo 2022 m. jis vadovauja savo \u012fkurtai Christian Doppler Vidin\u0117s ausies tyrim\u0173 laboratorijai Vienoje. Ten jis su komanda tiria veikli\u0105sias med\u017eiagas klausos sutrikimams gydyti.<\/em><\/p>\n

\u0160ioje ir kitose tyrim\u0173 \u012fstaigose kuriamos terapijos ateityje gali i\u0161 esm\u0117s pakeisti klausos sutrikim\u0173 gydym\u0105 ir suteikti nauj\u0173 galimybi\u0173 daugeliui \u017emoni\u0173. Ta\u010diau svarbu pabr\u0117\u017eti: u\u017e klinikini\u0173 tyrim\u0173 rib\u0173 \u0161ios terapijos kol kas dar n\u0117ra prieinamos pacientams. O patikrinti kochleariniai implantai (KI) ir ateityje i\u0161liks svarbi gydymo galimyb\u0117. Pokalbyje prof. Arnoldner paai\u0161kina, kas i\u0161 ties\u0173 gali pasikeisti ateityje. Nuo gegu\u017e\u0117s prad\u017eios jis yra Vienos universiteto LOR klinikos vadovas.<\/em><\/p>\n

MK-B: Jei taptum\u0117te Vienos universitetin\u0117s aus\u0173, nosies ir gerkl\u0117s (LOR) klinikos vadovu, kokie b\u016bt\u0173 j\u016bs\u0173 prioritetai?<\/strong><\/div>\n
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Prof. dr. Christoph Arnoldner, Christian Doppler Vidin\u0117s ausies tyrim\u0173 laboratorijos Vienoje \u012fk\u016br\u0117jas ir vadovas, nuo 2025 m. gegu\u017e\u0117s 1 d. vadovauja Vienos LOR universiteto klinikai. \u00a9 MedUni Wien\/felimage<\/p><\/div>\n

Arnolder<\/strong>: \u201eMan labai malonu perimti klinik\u0105, kurioje galime pacientams pasi\u016blyti plat\u0173 ir moderniausi\u0105 gydym\u0105. Atliekame sud\u0117tingas onkologines operacijas, taip pat estetin\u0119 chirurgij\u0105 ar kochlearini\u0173 implant\u0173 operacijas d\u0117l klausos praradimo. Operuojame tiek vaikus, tiek vyresnio am\u017eiaus pacientus.\u201c<\/p>\n

Kitas svarbus universiteto klinikos tikslas \u2013 gydytoj\u0173 rengimas. Tai apima t\u0119stinio mokymo programas, pavyzd\u017eiui, tarptautiniu mastu akredituotas vieneri\u0173 ar dvej\u0173 met\u0173 klinikines sta\u017euotes geriausiose klinikose Kanadoje, JAV, Australijoje ir Anglijoje. Tokiu b\u016bdu sukauptos \u017einios turi prisid\u0117ti prie optimalios pacient\u0173 prie\u017ei\u016bros.<\/p>\n

\u201eMan labai svarbu remti mokslinius tyrimus \u2013 ypa\u010d tas sritis, kurios dar neturi deramo pripa\u017einimo. Stengiam\u0117s stiprinti moksl\u0105 bendradarbiaudami su kitomis klinikomis. Mano paties tyrim\u0173 kryptis yra klausa. Siekiame, naudodami naujas med\u017eiagas, naujus implantus ar gen\u0173 terapij\u0105, atkurti klaus\u0105.\u201c<\/p>\n

MK-B: Kas yra Vienos LOR klinika?<\/em><\/strong><\/p>\n

Arnolder:<\/strong>\u00a0\u201eMes esame seniausia LOR klinika pasaulyje. Viena \u2013 miestas, susij\u0119s su XIX ir XX a. sand\u016bros \u017eymiu otorinolaringologu<\/em> Adamu Politzeriu, taip pat \u010dia buvo panaudotas pirmasis daugiakanalis kochlearinis implantas, leid\u017eiantis i\u0161 ties\u0173 atkurti klausos jutimo organo funkcij\u0105.<\/p>\n

Ta\u010diau negalime gyventi vien praeitimi: \u0161iandien esame tarp geriausi\u0173 klinik\u0173 pasaulyje visose aus\u0173, nosies ir gerkl\u0117s medicinos srityse \u2013 tiek pacient\u0173 prie\u017ei\u016bros, tiek vis labiau ir mokslini\u0173 tyrim\u0173 srityje.\u201c<\/p>\n

MK-B: Transliaciniai tyrimai \u2013 per\u0117jimas nuo mokslo prie praktikos \u2013 yra vienas pagrindini\u0173 j\u016bs\u0173 laboratorijos tiksl\u0173.<\/em><\/strong><\/p>\n

Tai yra m\u016bs\u0173, kaip klinikini\u0173 tyr\u0117j\u0173, stipryb\u0117. Otorinolaringologija n\u0117ra centrin\u0117 medicinos sritis, be to, ji nagrin\u0117ja labai smulkias strukt\u016bras. Daugelis proces\u0173 \u2013 klausos sutrikimai, spengimas ausyse, uosl\u0117s praradimas, alergijos \u2013 vis dar n\u0117ra pakankamai suprasti. Kaip klinikiniai gydytojai, mes \u017einome, kur slypi problema. Tyrimuose j\u0105 nagrin\u0117jame kryptingai ir darome visk\u0105, kad rezultatai kuo grei\u010diau pasiekt\u0173 klinikin\u0119 praktik\u0105.<\/p>\n

Pasaulyje apie 1,5 milijardo \u017emoni\u0173 turi klausos sutrikim\u0173 \u2013 pana\u0161iai tiek pat, kiek sergan\u010di\u0173j\u0173 auk\u0161tu kraujosp\u016bd\u017eiu. Auk\u0161tam kraujosp\u016bd\u017eiui yra daugiau nei 500 gydymo b\u016bd\u0173, ta\u010diau n\u0117ra n\u0117 vieno patvirtinto vaisto, kuris atkurt\u0173 klaus\u0105. Labai nemalonu pacientams, patyrusiems staig\u0173 klausos praradim\u0105 ar spengim\u0105 ausyse, sakyti: \u201eMes i\u0161 ties\u0173 ne\u017einome, kas dabar vyksta j\u016bs\u0173 vidin\u0117je ausyje.\u201c<\/p>\n

Mes norime geriau suprasti, kas vyksta vidin\u0117je ausyje atsiradus klausos praradimui! Ir norime rasti nauj\u0173 vaist\u0173, kad gal\u0117tume pasi\u016blyti pacientams realias galimybes.<\/p>\n

MK-B: Kartu su komanda tyrin\u0117jate veikli\u0105j\u0105 med\u017eiag\u0105 AC102, kuri suteikia nauj\u0173 vil\u010di\u0173 esant \u016bminiam staigiam klausos praradimui.<\/em><\/strong><\/p>\n

\u0160iuo metu, esant staigiam klausos praradimui ar spengimui ausyse, skiriame dideles kortizono dozes \u2013 ta\u010diau turime pripa\u017einti, kad rezultatai da\u017enai b\u016bna kukl\u016bs. Beveik prie\u0161 de\u0161imt met\u0173 \u012f mus kreip\u0117si labai ma\u017ea farmacijos \u012fmon\u0117 i\u0161 Vokietijos \u2013 \u201eCharit\u00e9\u201c at\u0161aka. Jie papra\u0161\u0117 \u012fvertinti nauj\u0105 veikli\u0105j\u0105 med\u017eiag\u0105, paslaptingai skamban\u010di\u0105 AC102 (angl. tariama \u201eA-C-one-O-two\u201c). AC rei\u0161kia \u201eAudioCure\u201c \u2013 \u012fmon\u0119, suk\u016brusi\u0105 \u0161i\u0105 med\u017eiag\u0105.<\/p>\n

Per pastaruosius metus \u0161i\u0105 veikli\u0105j\u0105 med\u017eiag\u0105 pavyko perkelti i\u0161 Petri l\u0117k\u0161tel\u0117s tyrim\u0173 per gyv\u016bn\u0173 modelius iki II faz\u0117s klinikinio tyrimo. Tai rei\u0161kia, kad dabar ji tiriama didel\u0117je daugiacentr\u0117je studijoje daugelyje Europos \u0161ali\u0173 su pacientais, patyrusiais \u016bmin\u012f staig\u0173 klausos praradim\u0105. Tikim\u0117s, kad \u0161is vaistas ilgainiui gal\u0117t\u0173 pakeisti gydymo galimybes.<\/p>\n

GG: Kod\u0117l iki \u0161iol gydytojai skirdavo kortizon\u0105?<\/em><\/strong><\/p>\n

Kas tiksliai vyksta vidin\u0117je ausyje staigaus klausos praradimo metu, iki \u0161iol n\u0117ra iki galo ai\u0161ku \u2013 ir tai yra viena i\u0161 tem\u0173, kurias norime geriau i\u0161tirti savo laboratorijoje. Manoma, kad bent daliai pacient\u0173 klausos praradim\u0105 sukelia u\u017edegimas vidin\u0117je ausyje, tod\u0117l ir skiriamas kortizonas. Kortizonas yra nat\u016bralus organizmo hormonas, labai veiksmingai ma\u017einantis u\u017edegim\u0105, ta\u010diau jis neturi teigiamo poveikio nervin\u0117ms l\u0105stel\u0117ms ir skaiduloms.<\/p>\n

MK-B: Kuo skiriasi naujasis po\u017ei\u016bris?<\/em><\/strong><\/p>\n

AC102 ne tik veikia prie\u0161u\u017edegimi\u0161kai, bet ir i\u0161 ties\u0173 apsaugo nervus. Klausos praradimas labai susij\u0119s su tuo, kad ma\u017edaug 13 000 mikrometr\u0173 dyd\u017eio jutimini\u0173 l\u0105steli\u0173 ausyje \u2013 jas pa\u017eeidus \u2013 nebeatauga. Naudodami AC102 galime apsaugoti \u0161ias jutimines l\u0105steles, ypa\u010d jungt\u012f tarp plaukuotosios l\u0105stel\u0117s ir nervin\u0117s skaidulos. Tai svarbu tiek klausos praradimo, tiek regeneracijos procesams.<\/p>\n

GG: Ar esamiems KI naudotojams arba pacientams, kurie ilg\u0105 laik\u0105 buvo negirdintys ir negydyti, galima tik\u0117tis, kad AC102 atkurs j\u0173 klaus\u0105?<\/em><\/strong><\/p>\n

Taip, jei AC102 skiriamas anksti, klausa tur\u0117t\u0173 atsistatyti, nes pasteb\u0117tas labai teigiamas poveikis neuronams. Be to, AC102 u\u017etikrina daug veiksmingesn\u0119 likutin\u0117s klausos apsaug\u0105 nei \u0161iuo metu naudojamas kortizonas kochlearin\u0117s implantacijos metu, o tai gal\u0117t\u0173 suteikti lemiam\u0105 prana\u0161um\u0105.<\/p>\n

MK-B: Kaip AC102 padeda i\u0161saugoti likutin\u0119 klaus\u0105?<\/em><\/strong><\/p>\n

KI implantuojame pacientams, kuriems klausos aparatai jau nebeveikia. Pastaraisiais metais paai\u0161k\u0117jo, kad KI gali pad\u0117ti ir tiems pacientams, kurie dar turi \u0161iek tiek likutin\u0117s klausos. Ta\u010diau mes norime j\u0105 i\u0161saugoti, nes i\u0161saugota likutin\u0117 klausa kartu su kochleariniu implantu veikia geriau nei vien implantas.<\/p>\n

Atliekant kochlearin\u0119 implantacij\u0105, elektrod\u0173 laikiklis \u012fvedamas \u012f sraig\u0119. Taip atveriama \u201e\u0161venta\u201c vidin\u0117s ausies erdv\u0117 \u2013 ir tai paprastai sukelia klausos praradimo rizik\u0105. Tod\u0117l turime tobulinti likutin\u0117s klausos i\u0161saugojimo metodus. Tai apima itin tikslias chirurgines technikas: labai atsarg\u0173 sraig\u0117s atv\u0117rim\u0105, atraumatini\u0173 elektrod\u0173 naudojim\u0105, taip pat med\u017eiag\u0173, saugan\u010di\u0173 vidin\u0117s ausies strukt\u016bras, skyrim\u0105.<\/p>\n

\u010cia svarbus vaidmuo tenka AC102: \u012fvedus svetimk\u016bn\u012f \u012f vidin\u0119 aus\u012f nei\u0161vengiamai kyla u\u017edegimas. AC102 slopina \u0161i\u0105 u\u017edegimin\u0119 reakcij\u0105 ir apsaugo jungtis tarp vidin\u0117s ausies plaukuot\u0173j\u0173 l\u0105steli\u0173 ir nervini\u0173 skaidul\u0173. \u0160iuo metu vyksta II faz\u0117s tyrimas su pacientais, patyrusiais staig\u0173 klausos praradim\u0105. Jei rezultatai bus teigiami, bus prad\u0117tas III faz\u0117s tyrimas, o vaistas bus vertinamas ir kitoms indikacijoms \u2013 pavyzd\u017eiui, likutin\u0117s klausos apsaugai kochlearin\u0117s implantacijos metu.<\/p>\n

________ __________<\/p>\n

MK-B: Pastaraisiais metais vis daugiau tyrim\u0173 rodo, kad gen\u0173 terapija gali b\u016bti viena i\u0161 klausos sutrikim\u0173 gydymo kryp\u010di\u0173.<\/em><\/strong><\/p>\n

Dar visai neseniai pacientams, patyrusiems staig\u0173 klausos praradim\u0105, be audiologini\u0173 tyrim\u0173 da\u017eniausiai buvo atliekami tik vaizdiniai tyrimai, o genetiniai veiksniai buvo vertinami tik i\u0161skirtiniais atvejais. \u0160iandien genetinio pagrindo tyrimas tampa vienu i\u0161 standartini\u0173 tyrim\u0173, nes genetika turi didel\u0119 reik\u0161m\u0119 \u2013 juk klausos praradimas n\u0117ra vienodas visiems.<\/p>\n

Pirmieji vaikai, turintys otoferlino sukelt\u0105 kurtum\u0105 \u2013 ypating\u0105 \u012fgimt\u0105 klausos sutrikim\u0105 \u2013 jau gavo gen\u0173 terapij\u0105 ir dabar girdi. \u0160iuo metu \u017einoma daugiau nei 200 genetinio kurtumo form\u0173..[1]<\/strong><\/a>\u00a0 Otoferlino kurtumas yra viena j\u0173; pasaulyje ja serga apie 200 000 \u017emoni\u0173, tod\u0117l ji laikoma reta liga. Ta\u010diau \u0161iai pacient\u0173 grupei dabar atsirado reali viltis.<\/em><\/p>\n

Vaik\u0173, turin\u010di\u0173 otoferlino kurtum\u0105, vidin\u0117 ausis yra normali, plaukuotosios l\u0105stel\u0117s taip pat normalios, ta\u010diau joms tr\u016bksta vieno baltymo \u2013 otoferlino. D\u0117l to nei\u0161siskiria signalas, reikalingas gird\u0117jimui. Naujoji terapija \u012f plaukuot\u0105sias l\u0105steles \u012fveda tr\u016bkstam\u0105 genetin\u0119 informacij\u0105, signalas v\u0117l perduodamas \u2013 ir i\u0161 ties\u0173 \u0161ie vaikai pradeda gird\u0117ti, net ir be kochlearinio implanto.<\/p>\n

MK-B: Kur matote did\u017eiausi\u0105 potencial\u0105 gydant klausos sutrikimus \u2013 implantuose, medikamentin\u0117je terapijoje ar genetin\u0117se modifikacijose?<\/em><\/strong><\/p>\n

Tik\u0117tina, kad ateitis bus \u0161i\u0173 metod\u0173 derinys. Kochleariniai implantai ir toliau bus reikalingi, kad pad\u0117t\u0173 daugeliui pacient\u0173. Ta\u010diau bus ir specifini\u0173 genetini\u0173 klausos praradimo form\u0173, kuriose svarb\u0173 vaidmen\u012f atliks gen\u0173 terapija. Taip pat galimas kombinuotas po\u017ei\u016bris: pasitelkus gen\u0173 terapij\u0105, veikian\u010di\u0105 vidin\u0117s ausies nervines l\u0105steles, gal\u0117sime pad\u0117ti CI pacientams dar geriau gird\u0117ti su savo implantais.<\/p>\n

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[1]<\/a>\u00a0Prof. Dr. Ellen Reisinger\u00a0Gene Therapy Heals Children with Congenital Deafness\u00a0<\/a>| Tagesschau.de<\/a><\/p>\n<\/div>

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Norime pad\u0117koti Martinui Krenek-Burgeriui<\/strong>, \u201eDoctors Week\u201c redaktoriaus pavaduotojui, u\u017e \u012fdomius klausimus tinklalaid\u0117je \u201eH\u00f6rgang\u201c<\/strong>, o ypa\u010d prof. dr. Christophui Arnoldneriui<\/strong> \u2013 u\u017e galimyb\u0119 u\u017eduoti papildom\u0173 klausim\u0173. Taip pat d\u0117kojame leidyklai \u201eSpringer-Medizin\u201c ir jos partneriui MedUni Wien u\u017e leidim\u0105 perimti dideles \u0161io tinklalaid\u0117s epizodo dalis ir pritaikyti jas m\u016bs\u0173 skaitytojams. Vis\u0105 pokalb\u012f \u201eHope for listening\u201c<\/strong> su prof. dr. Christophu Arnoldneriu rasite tinklalaid\u017ei\u0173 serijoje \u201eH\u00f6rgang\u201c svetain\u0117je www.springermedizin.at<\/a>, visose populiariausiose tinklalaid\u017ei\u0173 platformose bei spektrum.de<\/a>.<\/p>\n<\/div>

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Prof. Christoph Arnoldner pasakoja apie savo prioritetus, tapus naujuoju Vienos universiteto LOR klinikos vadovu, ir apie dabartinius mokslinius projektus, galin\u010dius i\u0161 esm\u0117s pakeisti klausos terapij\u0105.<\/p>\n","protected":false},"author":10,"featured_media":32554,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[411],"tags":[],"class_list":["post-32511","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sveikata"],"yoast_head":"\nAr klausos praradim\u0105 bus galima atkurti? - Lithuanian<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lifelonghearing.com\/lt\/ar-klausos-praradima-bus-galima-atkurti\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ar klausos praradim\u0105 bus galima atkurti? 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