{"id":17699,"date":"2022-03-08T09:00:27","date_gmt":"2022-03-08T08:00:27","guid":{"rendered":"https:\/\/lifelonghearing.com\/?p=17699"},"modified":"2025-04-22T15:50:39","modified_gmt":"2025-04-22T15:50:39","slug":"a-hallas-rehabilitacio-jovojevel-kapcsolatos-kutatasok","status":"publish","type":"post","link":"https:\/\/lifelonghearing.com\/hu\/a-hallas-rehabilitacio-jovojevel-kapcsolatos-kutatasok\/","title":{"rendered":"A hall\u00e1s-rehabilit\u00e1ci\u00f3 j\u00f6v\u0151j\u00e9vel kapcsolatos kutat\u00e1sok"},"content":{"rendered":"

Hall\u00e1s-rehabilit\u00e1ci\u00f3: G\u00e9nter\u00e1pia \u00e9s optikai cochle\u00e1ris implant\u00e1tum<\/h1><\/div>

Az Innsbruckban tartott 2021-es Osztr\u00e1k F\u00fcl-Orr-G\u00e9g\u00e9szeti Konferencia utols\u00f3 napj\u00e1n a hall\u00e1s-rehabilit\u00e1ci\u00f3 t\u00e1voli j\u00f6v\u0151je \u00e9s az a t\u00e9m\u00e1val kapcsolatos k\u00f6z\u00e9pt\u00e1v\u00fa kutat\u00e1sok ker\u00fcltek a k\u00f6z\u00e9ppontba.<\/strong><\/p>\n<\/div>

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2013-ban P.D. DI DDr. Ingeborg Hochmair, az ausztriai implant\u00e1tum-gy\u00e1rt\u00f3\u00a0MED-EL<\/a>\u00a0v\u00e1llalat alap\u00edt\u00f3ja, Prof. Dr. Blake S. Wilson, a Duke Egyetem kutat\u00f3ja, valamint Prof. Dr. Graeme M. Clark, a Melbourne-i Egyetem munkat\u00e1rsa kapta a klinikai kutat\u00e1s\u00e9rt j\u00e1r\u00f3 Lasker-DeBakey-d\u00edjat a modern cochle\u00e1ris implant\u00e1tumok fejleszt\u00e9s\u00e9\u00e9rt. Mivel a hall\u00e1s implant\u00e1ci\u00f3 2021-ben \u00fcnnepelte 30. \u00e9vfordul\u00f3j\u00e1t, a Lasker-DeBakey-d\u00edjat az orvosi alapkutat\u00e1sok kateg\u00f3ri\u00e1ban h\u00e1rom olyan kutat\u00f3 vehette \u00e1t, akik jelent\u0151s munk\u00e1t v\u00e9geztek a\u00a0cochle\u00e1ris implant\u00e1tumok<\/a>\u00a0j\u00f6v\u0151je kapcs\u00e1n. N\u00e9v szerint: Prof. Karl Deisseroth, M.D., Ph.D. a kaliforniai Stanford Egyetem kutat\u00f3ja, Prof. Peter Hegemann a berlini Humboldt Egyetem munkat\u00e1rsa \u00e9s Prof. Dieter Oesterhelt, a Max Planck Biok\u00e9miai Int\u00e9zet kutat\u00f3ja. Kutat\u00e1saik sor\u00e1n a f\u00e9ny\u00e9rz\u00e9keny feh\u00e9rje mikroorganizmusokat \u00e9s ezeknek az optogenetik\u00e1ban t\u00f6rt\u00e9n\u0151 felhaszn\u00e1l\u00e1si lehet\u0151s\u00e9geit vizsg\u00e1lt\u00e1k. Ez a protein az optikai cochle\u00e1ris implant\u00e1tumok fejleszt\u00e9s\u00e9nek el\u0151felt\u00e9tele, amire a szak\u00e9rt\u0151k komoly elv\u00e1r\u00e1sokkal tekintenek.<\/p>\n

A F\u00fcl-Orr-G\u00e9g\u00e9szeti Konferenci\u00e1n, Prof. Dr. Stefan Volkenstein \u00f6sszefoglalta a f\u00fclseb\u00e9szet j\u00f6v\u0151beli, a digitaliz\u00e1l\u00e1s \u00e9s technol\u00f3giai fejl\u0151d\u00e9s \u00e1ltal fellend\u00fcl\u00e9st mutat\u00f3 fejleszt\u00e9si lehet\u0151s\u00e9geit, melyek a hall\u00e1sjav\u00edt\u00f3 implant\u00e1tumokat is \u00e9rintik. P\u00e9ld\u00e1nak ok\u00e1\u00e9rt, a tov\u00e1bbfejlesztett k\u00e9palkot\u00e1si megold\u00e1sok lehet\u0151v\u00e9 teszik az egy\u00e9nre szabott cochle\u00e1ris implant\u00e1tumok haszn\u00e1lat\u00e1t.<\/p>\n

Volkenstein professzor t\u00f6bb lehet\u0151s\u00e9get is felv\u00e1zolt a CI j\u00f6v\u0151beli megval\u00f3s\u00edt\u00e1sa kapcs\u00e1n. Amellett, hogy sok CI-haszn\u00e1l\u00f3 \u00e1lma egy teljesen be\u00fcltetett rendszer, az optikai stimul\u00e1ci\u00f3val \u00e9s a hall\u00e1s \u00e1ltal\u00e1nos helyre\u00e1ll\u00edt\u00e1s\u00e1val az implant\u00e1tumok gyorsan elavult eszk\u00f6z\u00f6kk\u00e9 v\u00e1lhatnak.<\/p>\n

A j\u00f3 hall\u00e1s\u00e9rt felel\u0151s g\u00e9nek<\/h2>\n

A nem genetikai okok miatt szerzett (vagyis a nem sz\u00fclet\u00e9skor fenn\u00e1ll\u00f3) hall\u00e1sk\u00e1rosod\u00e1s eset\u00e9ben a f\u00fcl \u00e9rz\u00e9kel\u0151sejtjeit a legfejlettebb g\u00e9nter\u00e1pi\u00e1val pr\u00f3b\u00e1lj\u00e1k k\u00f6zvetlen\u00fcl \u00fajraalkotni. \u201eSz\u00e1mos tanulm\u00e1ny igazolja, hogy a sejtek ilyen jelleg\u0171 \u00fajb\u00f3li megalkot\u00e1sa lehets\u00e9ges\u201d \u2013 magyar\u00e1zta el\u0151ad\u00e1s\u00e1ban Ellen Reisinger a T\u00fcbingeni Egyetemi K\u00f3rh\u00e1z professzora. \u201eViszont eddig csak egyetlen tanulm\u00e1nyban siker\u00fclt bemutatni, hogy ez az elj\u00e1r\u00e1s jobb hall\u00e1st eredm\u00e9nyez. A probl\u00e9ma az, hogy ezt az eredm\u00e9nyt m\u00e9g nem siker\u00fclt lem\u00e1solni.\u201d Ebb\u0151l kifoly\u00f3lag nem lehet megj\u00f3solni, hogy egy ilyen jelleg\u0171 ter\u00e1pia megval\u00f3s\u00edthat\u00f3 lesz-e, \u00e9s ha igen, akkor mikor. A kisgyerekkorban el\u0151fordul\u00f3 hall\u00e1sk\u00e1rosod\u00e1sok 80 sz\u00e1zal\u00e9ka genetikai eredet\u0171 \u00e9s ezen genetikai elv\u00e1ltoz\u00e1sok t\u00f6bb, mint 70 sz\u00e1zal\u00e9ka kifejezetten a hall\u00e1st \u00e9rinti. Viszont azt neh\u00e9z meg\u00e1llap\u00edtani, hogy pontosan melyik g\u00e9n felel\u0151s az adott probl\u00e9m\u00e1\u00e9rt: a recessz\u00edv g\u00e9nvari\u00e1nsok eset\u00e9ben 78 k\u00fcl\u00f6nb\u00f6z\u0151 g\u00e9n okozhatja a betegs\u00e9get,<\/p>\n

\u00e9s legal\u00e1bb tov\u00e1bbi 23 g\u00e9n kapcsolata val\u00f3sz\u00edn\u0171s\u00edthet\u0151. Akkor m\u00e9g nem nem eml\u00edtett\u00fck az egy\u00e9b, eleddig ismeretlen okokat.<\/p>\n

\u00cdg\u00e9retes g\u00e9nter\u00e1piai megk\u00f6zel\u00edt\u00e9s<\/h2>\n

Ahogy l\u00e1that\u00f3, a hall\u00e1sk\u00e1rosod\u00e1st rengeteg k\u00fcl\u00f6nb\u00f6z\u0151 g\u00e9n okozhatja, ez\u00e9rt egyf\u00e9le g\u00e9nter\u00e1pi\u00e1val nem orvosolhat\u00f3 a probl\u00e9ma. Emellett egy ilyen ter\u00e1pia el\u0151felt\u00e9tele, hogy a hall\u00e1sk\u00e1rosod\u00e1s t\u00edpusa mellett minden egyes beteg eset\u00e9ben a betegs\u00e9g\u00e9rt felel\u0151s megfelel\u0151 g\u00e9nt is pontosan azonos\u00edts\u00e1k. Sok esetben, korai alkalmaz\u00e1sa n\u00e9lk\u00fcl a g\u00e9nter\u00e1pia sem jelenthet megold\u00e1st. P\u00e9ld\u00e1ul, \u00edg\u00e9retes eredm\u00e9nyek sz\u00fclettek egy egereken v\u00e9gzett k\u00eds\u00e9rlet ter\u00e1pi\u00e1s elj\u00e1r\u00e1sa kapcs\u00e1n, viszont ez a k\u00fcl\u00f6nleges ter\u00e1pia csak abban az esetben alkalmazhat\u00f3, ha a sikets\u00e9g t\u00e9ny\u00e9t m\u00e1r az anyam\u00e9hben siker\u00fcl meg\u00e1llap\u00edtani. A betegs\u00e9get okoz\u00f3 g\u00e9nhib\u00e1t m\u00e1r a terhess\u00e9g 18. hete el\u0151tt meg kell tal\u00e1lni! \u201eSzerintem nem szabad teljesen elvetni ezt a lehet\u0151s\u00e9get, viszont alkalmaz\u00e1sa olyan t\u00e1volinak t\u0171nik, mint a Mars ben\u00e9pes\u00edt\u00e9se\u201d \u2013 osztja meg vel\u00fcnk gondolatait Reisinger professzor, g\u00e9nter\u00e1pia-specialista.<\/p>\n

\u0150 maga is egy, a hall\u00e1sk\u00e1rosod\u00e1si esetek k\u00e9t sz\u00e1zal\u00e9k\u00e1t okoz\u00f3 genetikai mut\u00e1ci\u00f3t orvosol\u00f3 g\u00e9nter\u00e1pia fejleszt\u00e9s\u00e9n dolgozik. A klinikai vizsg\u00e1latok m\u00e1r folyamatban vannak. Azok a g\u00e9nter\u00e1pia fejleszt\u00e9sek a leg\u00edg\u00e9retesebbek, melyek a prot\u00e9zis megold\u00e1sokkal megval\u00f3s\u00edtott j\u00f6v\u0151beli optikai cochle\u00e1ris implant\u00e1tumok alapjait adj\u00e1k.<\/p>\n

Jobb hall\u00e1s cochle\u00e1ris implant\u00e1tummal<\/h2>\n

Az eg\u00e9szs\u00e9ges bels\u0151 f\u00fclben a hang k\u00f3dol\u00e1s\u00e1ra a bels\u0151 f\u00fcl azon r\u00e9sz\u00e9n ker\u00fcl sor, ahol az adott hang stimul\u00e1l\u00e1sa megval\u00f3sul. A cochle\u00e1ris implant\u00e1tumokn\u00e1l egy elektromos \u00e1ramimpulzus seg\u00edts\u00e9g\u00e9vel a stimul\u00e1ci\u00f3 a term\u00e9szetes stimul\u00e1ci\u00f3s ponthoz legk\u00f6zelebb es\u0151 helyen val\u00f3sul meg. Ezt a folyamatot Ionos Stimul\u00e1ci\u00f3nak nevezz\u00fck. Ezt az id\u0151alap\u00fa k\u00f3dol\u00e1st a m\u00e9ly hangokra egyed\u00fcl a MED-EL CI eszk\u00f6zei alkalmazz\u00e1k.<\/p>\n

Emellett, a modern cochle\u00e1ris implant\u00e1tumok gyenges\u00e9ge, hogy az eg\u00e9szs\u00e9ges f\u00fclh\u00f6z k\u00e9pest viszonylag alacsony frekvencia felbont\u00e1ssal dolgoznak, \u00edgy a hangok k\u00f6z\u00f6tti k\u00fcl\u00f6nbs\u00e9geket nem lehet olyan j\u00f3l \u00e9szlelni. Ennek az az oka, hogy az \u00e1ramimpulzusok az akt\u00edv kapcsolat k\u00f6r\u00fcl l\u00e9trehoznak egy saj\u00e1t elektromos mez\u0151t, amely a szomsz\u00e9dos ter\u00fcleteket is gerjeszti ugyanabban az id\u0151pontban. \u201eEmiatt mindegy, hogy 12 vagy 24 csatorn\u00e1t haszn\u00e1lunk\u201d \u2013 magyar\u00e1zta Prof. Dr. Tobias Moser, a G\u00f6ttingeni Orvosi Egyetem Audiol\u00f3giai Idegtudom\u00e1nyi Int\u00e9zet\u00e9nek igazgat\u00f3ja. \u201e\u00c9s itt kaphat jelent\u0151s szerepet az optikai CI, amivel egyszerre ak\u00e1r t\u00f6bb csatorna is biztos\u00edthat\u00f3.\u201d Rem\u00e9nyeink szerint el\u00e9rik a 64 csatorn\u00e1t.<\/p>\n

Optikai cochle\u00e1ris implant\u00e1tumok<\/h2>\n

Az emberi idegimpulzus egy term\u00e9szetes ionos impulzus, emiatt haszn\u00e1lhat\u00f3 j\u00f3l egy\u00fctt az elektromos stimul\u00e1ci\u00f3s impulzussal. Ezzel szemben, a z\u00f6ld alga sejtjei a f\u00e9nyre \u00e9rz\u00e9kenyek. \u201eAz elj\u00e1r\u00e1sban rejl\u0151 tr\u00fckk, hogy megpr\u00f3b\u00e1ljuk a z\u00f6ld alga genetikai inform\u00e1ci\u00f3t \u00e1tvinni az emberi idegsejtbe\u201d \u2013 magyar\u00e1zta Moser professzor. A Lasker-DeBakey-d\u00edj orvosi alapkutat\u00e1sok kateg\u00f3ri\u00e1j\u00e1nak nyertesei, vagyis Deisseroth, Hegemann \u00e9s Oesterhelt professzorok ezt az elj\u00e1r\u00e1st pr\u00f3b\u00e1lt\u00e1k egereken megval\u00f3s\u00edtani. Az objekt\u00edv ABR (agyt\u00f6rzsi v\u00e1lasz audiomertia) m\u00e9r\u00e9si eredm\u00e9nyek \u00e9s a viselked\u00e9st elemz\u0151 vizsg\u00e1latok egyar\u00e1nt azt mutatt\u00e1k, hogy a hangz\u00e1shat\u00e1sok el\u00e9rhet\u0151k.<\/p>\n

\u201eEgy fejleszt\u00e9si folyamat k\u00f6zben j\u00e1runk, \u00e9s m\u00e9g rengeteg a tennival\u00f3nk!\u201d \u2013 magyar\u00e1zta Moser professzor, a g\u00e9nter\u00e1pi\u00e1ra, valamint orvosi technol\u00f3gi\u00e1kkal megval\u00f3sul\u00f3 optikai stimul\u00e1ci\u00f3s modulokra \u00e9s megfelel\u0151 k\u00f3dol\u00e1si strat\u00e9gi\u00e1kra utalva.<\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

Az Innsbruckban tartott 2021-es Osztr\u00e1k F\u00fcl-Orr-G\u00e9g\u00e9szeti Konferencia utols\u00f3 napj\u00e1n a hall\u00e1s-rehabilit\u00e1ci\u00f3 t\u00e1voli j\u00f6v\u0151je \u00e9s az a t\u00e9m\u00e1val kapcsolatos k\u00f6z\u00e9pt\u00e1v\u00fa kutat\u00e1sok ker\u00fcltek a k\u00f6z\u00e9ppontba.<\/p>\n","protected":false},"author":4,"featured_media":31932,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[418],"tags":[445,422,412],"class_list":["post-17699","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tudomany","tag-development","tag-hearing-implant-reliability","tag-hearing-implants"],"yoast_head":"\nA hall\u00e1s-rehabilit\u00e1ci\u00f3 j\u00f6v\u0151j\u00e9vel kapcsolatos kutat\u00e1sok - Hungary<\/title>\n<meta name=\"description\" content=\"Az Innsbruckban tartott 2021-es Osztr\u00e1k F\u00fcl-Orr-G\u00e9g\u00e9szeti Konferencia utols\u00f3 napj\u00e1n a hall\u00e1s-rehabilit\u00e1ci\u00f3 j\u00f6v\u0151je \u00e9s a t\u00e9m\u00e1val kapcsolatos kutat\u00e1sok ker\u00fcltek a k\u00f6z\u00e9ppontba.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lifelonghearing.com\/hu\/a-hallas-rehabilitacio-jovojevel-kapcsolatos-kutatasok\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A hall\u00e1s-rehabilit\u00e1ci\u00f3 j\u00f6v\u0151j\u00e9vel kapcsolatos kutat\u00e1sok - 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